Opportunity Information: Apply for PA 24 201
The NIH opportunity titled "Emergency Competitive Revision to Existing NIH Awards (Emergency Supplement - Clinical Trial Optional)" (PA-24-201) is a discretionary grant mechanism designed to quickly add funds to projects that already have an active NIH award when an emergency situation creates urgent, unexpected needs. The basic idea is not to start a brand-new standalone project, but to competitively revise an existing NIH-funded award so the current scope can be expanded, adapted, or redirected to address impacts tied to a major disaster event. The emergency trigger can be a presidentially declared disaster under the Stafford Act, a public health emergency declared by the HHS Secretary, or another local, regional, or national disaster that creates a clear and time-sensitive research, programmatic, or operational need.
A key feature of this program is that applications are only accepted when they respond to an "Emergency Notice of Special Interest" (NOSI). In practice, NIH Institutes and Centers (ICs) will publish emergency NOSIs specific to the event and the kind of work they want to support, and only applications submitted in response to one of those emergency NOSIs can be routed and considered under this funding opportunity announcement. Those applications are sent directly to the NIH awarding component that signed onto the emergency NOSI, which is NIH's way of keeping the review and funding pathway focused and fast-moving during urgent circumstances. If there is no active emergency NOSI from an NIH IC, an application cannot use this NOFO as a general-purpose supplement request.
The "clinical trial optional" label means a proposed revision may include clinical trial activities if the relevant emergency NOSI and the parent award context allow it, but a clinical trial is not required. In other words, the mechanism is flexible enough to support a range of emergency-related needs, from clinical and public health responses to other urgent, disaster-driven research or capacity requirements, as long as the request is tied to an existing NIH award and fits the specific emergency NOSI instructions.
Eligibility is broad and includes many of the standard applicant types NIH works with. Eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations that are not federally recognized tribal governments; public housing authorities and Indian housing authorities; nonprofits with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; and small businesses. NIH also highlights additional eligible groups such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and even non-domestic (non-U.S.) entities (foreign organizations), reflecting the reality that disasters and public health emergencies can have cross-jurisdictional and international dimensions.
The opportunity sits in NIH funding activity categories that include education, environment, and health, and it is associated with multiple CFDA (Assistance Listing) numbers: 93.113, 93.142, 93.143, 93.279, 93.307, and 93.846. The posting date is April 18, 2024, and the listed closing date is April 18, 2027, which generally signals a standing mechanism that can be used whenever NIH issues emergency NOSIs during that period rather than a single one-time deadline for one event. Specific award amounts are not spelled out in the provided listing (the award ceiling and expected awards fields are blank), which is typical for emergency supplement structures where budget size and the number of awards often depend on the scale of the emergency, the amount of emergency funding available, and the volume and quality of requests received.
Overall, this NOFO is best understood as NIH's emergency "on-ramp" for quickly modifying and bolstering existing NIH-funded projects to meet urgent disaster-related needs, with access controlled through event-specific emergency NOSIs and with flexibility to include clinical trials when appropriate.Apply for PA 24 201
- The National Institutes of Health in the education, environment, health sector is offering a public funding opportunity titled "Emergency Competitive Revision to Existing NIH Awards (Emergency Supplement - Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.142, 93.143, 93.279, 93.307, 93.846.
- This funding opportunity was created on 2024-04-18.
- Applicants must submit their applications by 2027-04-18.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: Emergency Competitive Revision to Existing NIH Awards (Emergency Supplement - Clinical Trial Optional) (PA-24-201)
What is PA-24-201?
PA-24-201 is an NIH discretionary grant mechanism that provides an emergency competitive revision (an emergency supplement) to an existing, active NIH award. It is intended to quickly add funds when an emergency situation creates urgent and unexpected needs tied to a major disaster event.
Is this funding for new, standalone projects?
No. This opportunity is designed to competitively revise an existing NIH-funded award. The purpose is to expand, adapt, or redirect the current scope of an active project to address disaster-related impacts and time-sensitive needs.
What kinds of situations can trigger eligibility for an emergency supplement under this opportunity?
The emergency trigger can include a presidentially declared disaster under the Stafford Act, a public health emergency declared by the HHS Secretary, or another local, regional, or national disaster that creates a clear and urgent research, programmatic, or operational need.
Can anyone apply at any time?
No. Applications are only accepted when they respond to an active "Emergency Notice of Special Interest" (NOSI). Without an active emergency NOSI issued by an NIH Institute or Center (IC), an application cannot be submitted under this funding opportunity as a general-purpose supplement request.
What is an Emergency Notice of Special Interest (NOSI), and why does it matter?
An emergency NOSI is an NIH-issued notice tied to a specific disaster event (and often to specific types of activities NIH wants to support). Only applications submitted in direct response to one of these emergency NOSIs can be routed and considered under PA-24-201.
Who reviews or receives the application?
Applications submitted in response to an emergency NOSI are sent directly to the NIH awarding component that signed onto that emergency NOSI. This helps NIH keep the review and funding pathway focused and fast-moving during urgent circumstances.
What does "Emergency Competitive Revision" mean in practice?
It means NIH is adding funds to an already active NIH award through a competitive process, so the existing project can be modified to meet urgent, disaster-driven needs. The goal is rapid support for unexpected requirements created by an emergency.
What does "Clinical Trial Optional" mean?
"Clinical Trial Optional" means the proposed revision may include clinical trial activities if allowed by the relevant emergency NOSI and consistent with the context of the parent award, but a clinical trial is not required.
Do proposed activities have to be related to the existing NIH award?
Yes. The request is intended to revise and build on an existing NIH-funded award. The proposed changes should expand, adapt, or redirect the current scope to address impacts connected to the emergency and to follow the specific emergency NOSI instructions.
What kinds of needs can this emergency supplement support?
The mechanism is described as flexible and can support a range of emergency-related needs, including clinical and public health responses and other urgent disaster-driven research, capacity, programmatic, or operational requirements, as long as they are tied to an existing NIH award and align with the emergency NOSI.
Which organizations are eligible to apply?
Eligibility is broad. Eligible applicants include (among others) state, county, city, or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; non-federally recognized Native American tribal organizations; public housing authorities and Indian housing authorities; nonprofits with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; and small businesses.
Are specific institution types highlighted as eligible?
Yes. NIH highlights additional eligible groups such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, HBCUs, TCCUs, faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions.
Can non-U.S. (foreign) organizations apply?
Yes. The eligibility description includes non-domestic (non-U.S.) entities (foreign organizations), reflecting that disasters and public health emergencies can have cross-jurisdictional and international dimensions.
What NIH funding activity categories are associated with this opportunity?
The opportunity is associated with NIH funding activity categories that include education, environment, and health.
What Assistance Listing (CFDA) numbers are associated with this opportunity?
The listing includes multiple Assistance Listing (CFDA) numbers: 93.113, 93.142, 93.143, 93.279, 93.307, and 93.846.
What are the key dates for this opportunity?
The posting date is April 18, 2024, and the listed closing date is April 18, 2027. This generally indicates a standing mechanism available during that period when NIH issues emergency NOSIs, rather than a single one-time deadline tied to a single event.
Is there a fixed award amount or maximum budget listed?
No specific award amounts are provided in the information given. The award ceiling and expected awards fields are blank, which is common for emergency supplement structures where budgets and the number of awards can depend on the scale of the emergency, available emergency funding, and the volume and quality of requests received.
How do I know whether I can use PA-24-201 for my situation?
Based on the information provided, you generally need (1) an active NIH award to revise, and (2) an active emergency NOSI issued by an NIH Institute or Center that matches the disaster event and the type of work you are proposing. If there is no active emergency NOSI, this opportunity cannot be used as a general supplement pathway.
What is the main purpose of PA-24-201 in plain terms?
It is NIH's emergency on-ramp for quickly modifying and strengthening existing NIH-funded projects so they can respond to urgent, disaster-related needs, with access controlled through event-specific emergency NOSIs and flexibility to include clinical trials when appropriate.
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| Summer Research Education Experience Program (R25 Clinical Trial Not Allowed) Apply for PAR 24 204 Funding Number: PAR 24 204 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System (U44 Clinical Trial Optional) Apply for PAR 24 294 Funding Number: PAR 24 294 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System (UG3/UH3 Clinical Trial Optional) Apply for PAR 24 293 Funding Number: PAR 24 293 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Emerging Global Leader Award (K43 Independent Clinical Trial Required) Apply for PAR 24 295 Funding Number: PAR 24 295 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Emerging Global Leader Award (K43 Independent Clinical Trial Not Allowed) Apply for PAR 24 296 Funding Number: PAR 24 296 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| CCRP Initiative: NIH Countermeasures Against Chemical Threats (CounterACT) Translational Exploratory/Developmental Research Projects (R21 Clinical Trial Not Allowed) Apply for PAR 25 114 Funding Number: PAR 25 114 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $275,000 |
| Time-Sensitive Research Opportunities in Environmental Health Sciences (R21 Clinical Trials Not Allowed) Apply for RFA ES 25 003 Funding Number: RFA ES 25 003 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $800,000 |
| Transformative Research to Address Health Disparities and Advance Health Equity (U01 Clinical Trial Optional) Apply for RFA NR 25 003 Funding Number: RFA NR 25 003 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $500,000 |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Senior Fellowship (Parent F33) Apply for PA 25 424 Funding Number: PA 25 424 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
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