Opportunity Information: Apply for PAR 23 034
The National Library of Medicine (NLM), part of the National Institutes of Health (NIH), is offering an R01 grant opportunity titled "NLM Research Grants in Biomedical Informatics and Data Science (Clinical Trial Optional)" (Funding Opportunity Number PAR-23-034). This program is designed to fund innovative research and development in biomedical informatics and data science, with a strong emphasis on methods and approaches that enable biomedical discovery and "data-powered health." The core idea is to support work that can take complex, interconnected streams of biomedical and health-related information and turn them into outputs that matter in the real world, such as scientific insights, improvements in clinical care, stronger public health practice, and benefits for personal wellness.
A defining feature of this opportunity is its focus on scalability, reproducibility, and generalizability. In practice, that means NLM is not only interested in one-off tools or results that work in a single dataset or setting, but in approaches that can be expanded, repeated by other teams, and applied across different environments and populations. The scope is intentionally broad across biomedical informatics and data science, but the announcement highlights particular interest in new and innovative methods that advance data-driven discovery in biomedical and clinical health sciences. It also explicitly welcomes domain-independent work, meaning methods, infrastructure, and frameworks that are scalable and reusable across many biomedical areas rather than being tightly tied to one narrow specialty.
The scientific and technical areas emphasized include discovery, curation, analysis, organization, and management of health-related data and digital objects. That can include research that improves how data are captured and structured, how diverse data sources are integrated, how algorithms learn from complex biomedical signals, how knowledge is represented and made computable, and how data and digital artifacts are managed so that other researchers can find them, trust them, and reuse them. Because the program stresses translation into insights and practice, proposed work is expected to connect methodological innovation to meaningful biomedical or health applications, even when the contribution is primarily foundational or infrastructure-oriented.
The award mechanism is a discretionary grant using the NIH R01 activity code, with clinical trials listed as optional, indicating applicants may propose studies with or without a clinical trial component as appropriate to the research aims. The listed CFDA numbers are 93.310 and 93.879. The opportunity shows an award ceiling of $250,000, and the original closing date is January 7, 2026. (The posting does not specify an expected number of awards in the provided text.)
Eligibility is broad and includes many types of U.S. organizations and governmental entities, such as state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; and tribal organizations that are not federally recognized. It also includes nonprofits (with and without 501(c)(3) status), public housing authorities/Indian housing authorities, for-profit organizations (other than small businesses), and small businesses, as well as an "Other" category. In addition, the announcement calls out a range of other eligible applicants, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal agencies, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and non-U.S. entities (foreign organizations).
Overall, this funding opportunity is aimed at researchers and teams developing forward-looking biomedical informatics and data science capabilities, especially work that advances broadly reusable methods and systems for handling and learning from health-related data and digital resources, while keeping a clear line of sight to credible translation into biomedical knowledge, healthcare improvement, or public health impact.Apply for PAR 23 034
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "NLM Research Grants in Biomedical Informatics and Data Science (R01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310, 93.879.
- This funding opportunity was created on 2022-10-06.
- Applicants must submit their applications by 2026-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $250,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| AHEAD (Advancing Head and Neck Cancer Early Detection Research) (U01 Clinical Trial Not Allowed) Apply for RFA DE 23 013 Funding Number: RFA DE 23 013 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Avenir Award Program for Chemistry and Pharmacology of Substance Use Disorders (DP1- Clinical Trial Not Allowed) Apply for RFA DA 24 007 Funding Number: RFA DA 24 007 Agency: National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| Avenir Award Program for Genetics or Epigenetics of Substance Use Disorders (DP1 Clinical Trial Optional) Apply for PAR 23 021 Funding Number: PAR 23 021 Agency: National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| Comprehensive Partnerships to Advance Cancer Health Equity (CPACHE) (U54 Clinical Trial Optional) Apply for PAR 22 249 Funding Number: PAR 22 249 Agency: National Institutes of Health Category: Education, Health Funding Amount: $2,000,000 |
| Feasibility Studies to Build Collaborative Partnerships in Cancer Research (P20 Clinical Trial Not Allowed) Apply for PAR 22 239 Funding Number: PAR 22 239 Agency: National Institutes of Health Category: Education, Health Funding Amount: $375,000 |
| Precompetitive Collaboration on Liquid Biopsy for Early Cancer Assessment: Liquid Biopsy Research Laboratories (U01 Clinical Trial Not Allowed) Apply for RFA CA 23 018 Funding Number: RFA CA 23 018 Agency: National Institutes of Health Category: Education, Health Funding Amount: $600,000 |
| Functional Validation and/or Characterization of Genes or Variants Implicated in Substance Use Disorders (R21/R33 Clinical Trial Not Allowed) Apply for PAR 23 041 Funding Number: PAR 23 041 Agency: National Institutes of Health Category: Education, Health Funding Amount: $125,000 |
| Precompetitive Collaboration on Liquid Biopsy for Early Cancer Assessment: Data Management and Coordinating Unit (U24 Clinical Trial Not Allowed) Apply for RFA CA 23 019 Funding Number: RFA CA 23 019 Agency: National Institutes of Health Category: Education, Health Funding Amount: $450,000 |
| Targeting Inflammasomes in Substance Abuse and HIV (R01 Clinical Trial Not Allowed) Apply for RFA DA 24 003 Funding Number: RFA DA 24 003 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Targeting Inflammasomes in Substance Abuse and HIV (R21 Clinical Trial Not Allowed) Apply for RFA DA 24 004 Funding Number: RFA DA 24 004 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Investigating the Effects of Addictive Substances on Brain Developmental Trajectories Using Innovative Scalable Methods for Quantification of Cell Identity, Lineage and Connectivity (R01 - Clinical Trial Not Allowed) Apply for RFA DA 23 036 Funding Number: RFA DA 23 036 Agency: National Institutes of Health Category: Education, Health Funding Amount: $700,000 |
| Transformative Educational Advancement and Mentoring Network (TEAM) (R25 Clinical Trial Not Allowed) Apply for RFA CA 23 013 Funding Number: RFA CA 23 013 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| HEAL Initiative: Sleep Predictors of Opioid-Use Disorder Treatment Outcomes Program (R01 Clinical Trial Optional) Apply for RFA DA 23 059 Funding Number: RFA DA 23 059 Agency: National Institutes of Health Category: Education, Health Funding Amount: $3,000,000 |
| HEAL Initiative - Sleep Predictors of Opioid-Use Disorder Treatment Outcomes Program: Leadership and Data Co-ordinating Center (U01 Clinical Trial Optional) Apply for RFA DA 23 060 Funding Number: RFA DA 23 060 Agency: National Institutes of Health Category: Education, Health Funding Amount: $1,500,000 |
| Exploratory studies to investigate mechanisms of HIV infection, replication, latency, and/or pathogenesis in the context of substance use disorders (R61/R33 - Clinical Trial Not Allowed) Apply for RFA DA 24 002 Funding Number: RFA DA 24 002 Agency: National Institutes of Health Category: Education, Health Funding Amount: $350,000 |
| NCI Cancer Screening Research Network: ACCrual, Enrollment, and Screening Sites (ACCESS) Hub (UG1 Clinical Trial Required) Apply for RFA CA 23 020 Funding Number: RFA CA 23 020 Agency: National Institutes of Health Category: Education, Health Funding Amount: $750,000 |
| NCI Cancer Screening Research Network: Statistics and Data Management Center (UG1 Clinical Trial Required) Apply for RFA CA 23 021 Funding Number: RFA CA 23 021 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NCI Cancer Screening Research Network: Coordinating and Communication Center (UG1 Clinical Trial Required) Apply for RFA CA 23 022 Funding Number: RFA CA 23 022 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Mechanistic links between diet, lipid metabolism, and tumor growth and progression (UH2 Clinical Trial Not Allowed) Apply for PAR 23 052 Funding Number: PAR 23 052 Agency: National Institutes of Health Category: Education, Health Funding Amount: $275,000 |
| Mechanistic links between diet, lipid metabolism, and tumor growth and progression (U01 Clinical Trial Not Allowed) Apply for PAR 23 051 Funding Number: PAR 23 051 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
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