Opportunity Information: Apply for RFA NS 19 030
The Neuropathological Assessment of TBI-related Neurodegeneration and Neurocognitive Decline - Center Without Walls (NATBI CWOW) funding opportunity (RFA NS 19 030) is a National Institutes of Health cooperative agreement that supports a single, coordinated, multisite effort to study how traumatic brain injury (TBI) is linked to later-life neurodegeneration and cognitive decline. The overall goal is to build a comprehensive picture of the brain changes seen after TBI by combining standardized neuropathology with rich clinical histories, then connecting those postmortem findings to symptoms documented while individuals were alive. The project is structured as a "Center Without Walls," meaning it is meant to operate as a distributed consortium across sites rather than as a single physical center, with strong coordination and harmonized methods across participating institutions.
The scientific focus is on systematically characterizing neuropathological features in people with a history of TBI and determining how those features relate to neurocognitive outcomes and neurodegenerative disease. Applications are expected to examine how individual factors such as sex, age at the time of injury, and time since injury may shape neuropathological burden and clinical presentation. In parallel, the study should account for injury-related factors including severity and frequency of TBI, recognizing that a single severe injury and repeated mild injuries may produce different long-term patterns. A central expectation is to describe associations between the amount and type of neuropathology found at autopsy and antemortem clinicopathologic symptoms, meaning cognitive, behavioral, motor, and other neurologic changes observed prior to death that might align with specific pathological signatures.
A key deliverable is a clear estimate of the prevalence of several TBI-associated neurodegenerative outcomes within the participating brain bank populations. Specifically, the consortium is expected to outline how commonly it observes TBI-related parkinsonism, TBI-related Alzheimer's disease-like pathology, and chronic traumatic encephalopathy (CTE) among the cases available to the network. This implies not only identifying these entities using agreed-upon neuropathological criteria, but also placing them in context across sites so that differences in ascertainment, demographics, and injury exposure can be understood rather than confounded.
Data and resource sharing is not treated as optional in this announcement; it is a defining feature of the program. The FOA emphasizes broad sharing of both clinical and neuropathological data, with the intent of accelerating progress beyond the immediate awardee group. To support that, applicants are expected to develop a digital resource that enables distribution and sharing of assessed neuropathological tissue, which suggests a structured, accessible platform tied to standardized tissue assessment and associated metadata. In practice, this kind of resource is typically meant to make it easier for external investigators to discover what has been collected, understand how it was processed and scored, and request access under appropriate governance, while also encouraging consistency in how future samples are evaluated.
From an administrative standpoint, the mechanism is a U54 cooperative agreement, which generally signals substantial scientific or programmatic involvement by NIH staff in partnership with the awardee. The opportunity is labeled "Clinical Trial Not Allowed," indicating the funded activities should not include prospective interventional clinical trials. The eligible applicant pool is broad and includes federal-recognized tribal governments and tribal organizations, state and local governments, public and private institutions of higher education, nonprofit organizations with or without 501(c)(3) status, for-profit organizations (including small businesses), independent school districts, special district governments, and other entities as allowed by the FOA's eligibility details. The Department of Health and Human Services is the parent agency, with NIH as the awarding component, and the CFDA numbers listed are 93.853 and 93.866.
Logistically, the FOA anticipated one award, which reinforces that NIH intended to fund a single consortium able to bring multiple sites and brain bank resources into a unified framework. The award ceiling is listed as 0, which typically means applicants must refer to the FOA text for budget guidance rather than relying on a fixed maximum in the summary fields. The original posting date was February 25, 2019, with an original closing date of April 15, 2019, positioning it as a time-limited competition aimed at launching a coordinated national effort around neuropathology, clinical correlation, and open, reusable research resources for the TBI-neurodegeneration field.Apply for RFA NS 19 030
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Neuropathological Assessment of TBI-related Neurodegeneration and Neurocognitive decline - Center Without Walls (NATBI CWOW) (U54 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853, 93.866.
- This funding opportunity was created on Feb 25, 2019.
- Applicants must submit their applications by Apr 15, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Browse more opportunities from the same category: Health
Next opportunity: Specialty Crop Block Grant Program – Farm Bill
Previous opportunity: Small Business Innovation Research (SBIR) Program Phase I
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for RFA NS 19 030
Applicants also applied for:
Applicants who have applied for this opportunity (RFA NS 19 030) also looked into and applied for these:
| Funding Opportunity |
|---|
| Characterizing the Complications Associated with Therapeutic Blood Transfusions for Hemoglobinopathies Apply for CDC RFA DD19 1903 Funding Number: CDC RFA DD19 1903 Agency: Department of Health and Human Services, Centers for Disease Control - NCBDDD Category: Health Funding Amount: $375,000 |
| Implementing Evidence-Based Health Promotion Programs for Children with Attention-Deficit/Hyperactivity Disorder (ADHD) or Tourette Syndrome (TS) Apply for CDC RFA DD19 1904 Funding Number: CDC RFA DD19 1904 Agency: Department of Health and Human Services, Centers for Disease Control - NCBDDD Category: Health Funding Amount: $900,000 |
| 2019 Epidemiology and Laboratory Capacity for Prevention and Control of Emerging Infectious Diseases (ELC) Apply for CDC RFA CK19 1904 Funding Number: CDC RFA CK19 1904 Agency: Department of Health and Human Services, Centers for Disease Control - NCEZID Category: Health Funding Amount: Case Dependent |
| Early Detection of Certain Medical Conditions Related to Environmental Health Hazards Apply for CDC RFA TS19 1902 Funding Number: CDC RFA TS19 1902 Agency: Department of Health and Human Services, Centers for Disease Control - ATSDR Category: Health Funding Amount: $2,500,000 |
| Hospital Preparedness Program Cooperative Agreement Apply for EP U3R 19 001 Funding Number: EP U3R 19 001 Agency: Department of Health and Human Services, Assistant Secretary for Preparedness and Response Category: Health Funding Amount: $23,274,780 |
| Technical Assistance to Increase Tobacco Cessation Apply for CDC RFA DP19 1904 Funding Number: CDC RFA DP19 1904 Agency: Department of Health and Human Services, Centers for Disease Control - NCCDPHP Category: Health Funding Amount: $225,000 |
| Public Health Emergency Preparedness (PHEP) Cooperative Agreement Apply for CDC RFA TP19 1901 Funding Number: CDC RFA TP19 1901 Agency: Department of Health and Human Services, Centers for Disease Control - OPHPR Category: Health Funding Amount: $10,000,000 |
| Emerging Infectious Diseases Research Centers - Coordination Center (U01 Clinical Trial Not Allowed) Apply for RFA AI 19 029 Funding Number: RFA AI 19 029 Agency: Department of Health and Human Services, National Institutes of Health Category: Health Funding Amount: $500,000 |
| Preventing Maternal Deaths: Supporting Maternal Mortality Review Committees Apply for CDC RFA DP19 1908 Funding Number: CDC RFA DP19 1908 Agency: Department of Health and Human Services, Centers for Disease Control - NCCDPHP Category: Health Funding Amount: $600,000 |
| Geroscience Approaches to Alzheimer's Disease (R21 Clinical Trial Not Allowed) Apply for RFA AG 20 014 Funding Number: RFA AG 20 014 Agency: Department of Health and Human Services, National Institutes of Health Category: Health Funding Amount: $200,000 |
| Newborn Screening State Evaluation Program Apply for HRSA 19 097 Funding Number: HRSA 19 097 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: $150,000 |
| First Responders-Comprehensive Addiction and Recovery Act Apply for TI 19 004 Funding Number: TI 19 004 Agency: Department of Health and Human Services, Substance Abuse and Mental Health Services Adminis Category: Health Funding Amount: $800,000 |
| Rural Communities Opioid Response Program-Implementation Apply for HRSA 19 082 Funding Number: HRSA 19 082 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Rural Communities Opioid Response Program-Evaluation Apply for HRSA 19 083 Funding Number: HRSA 19 083 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Announcement of Availability of Funds for Data Analysis and Trends Research Grants Apply for PA FPR 19 002 Funding Number: PA FPR 19 002 Agency: Department of Health and Human Services, Office of the Assistant Secretary for Health Category: Health Funding Amount: $300,000 |
| Eliminate Tuberculosis in Ethiopia (ETBE) Apply for AID RFI 663 19 00002 Funding Number: AID RFI 663 19 00002 Agency: Agency for International Development, Ethiopia USAID-Addis Ababa Category: Health Funding Amount: Case Dependent |
| Good Health and Wellness in Indian Country Apply for CDC RFA DP19 1903 Funding Number: CDC RFA DP19 1903 Agency: Department of Health and Human Services, Centers for Disease Control - NCCDPHP Category: Health Funding Amount: $1,450,000 |
| Graduate Psychology Education (GPE) Program Apply for HRSA 19 002 Funding Number: HRSA 19 002 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Opioid Workforce Expansion Program (OWEP) Paraprofessionals Apply for HRSA 19 089 Funding Number: HRSA 19 089 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: $900,000 |
| Opioid Workforce Expansion Program (OWEP) Professionals Apply for HRSA 19 085 Funding Number: HRSA 19 085 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "RFA NS 19 030", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.