Opportunity Information: Apply for PAR 24 319
The NCI Continuing Umbrella of Research Experiences (CURE) Mentored Clinical Scientist Research Career Development Award (K08 Clinical Trial Required) is an NIH grant opportunity (PAR-24-319; CFDA 93.398) run by the National Cancer Institute to help clinically trained investigators build strong, independent research careers in cancer-related science. The core goal is career development: it provides funding and, importantly, protected time so a clinician with a doctoral clinical degree can spend several years in an intensive, closely supervised research and training experience. The program is meant to move awardees from mentored training into a position where they are ready to lead their own funded research programs that address major health needs, particularly in cancer.
This K08 is centered on developing clinical scientists in basic biomedical, behavioral, or translational cancer research, and it explicitly includes work focused on cancer health disparities. A defining feature is that it is part of NCI's CURE framework and is specifically aimed at advancing the careers of individuals from backgrounds that are nationally underrepresented in health-related science. In practical terms, the award is designed to strengthen research skills, publication track record, grant-writing readiness, and scientific independence through a structured mentored plan, with the expectation that recipients will be well-positioned to successfully compete for subsequent NIH research project grants such as an R03, R21, or R01.
As a "Clinical Trial Required" K08, applicants should expect that the proposed career development research plan must include a clinical trial component as defined by NIH policy. That requirement shapes both the training plan and the mentorship environment, since the candidate typically needs access to the clinical research infrastructure, regulatory support, and experienced clinical trial mentorship needed to conduct the trial responsibly and successfully.
The opportunity is categorized as a discretionary grant in the Education and Health funding activity area. A wide range of applicant organizations may apply, including public and private institutions of higher education, state and local governments, federally recognized tribal governments, tribal organizations (including those other than federally recognized tribal governments), independent school districts, special district governments, public housing/Indian housing authorities, nonprofits with or without 501(c)(3) status, for-profit organizations (other than small businesses), and small businesses. The notice also highlights additional eligible applicant types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with eligible federal agencies, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions. At the same time, foreign entities are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components (as NIH defines them in the NIH Grants Policy Statement) are not allowed.
Key administrative details included in the listing are an original closing date of January 7, 2028, and a creation date of December 6, 2024. The award ceiling and expected number of awards are not specified in the provided source text, which is common for NIH career development announcements where budget structure is often governed by institute-specific salary and research development support limits described in the full funding announcement. Overall, the program is best understood as a structured bridge for underrepresented clinician-scientists in cancer research, giving them mentored training, time, and resources to transition into independent, competitively funded investigators capable of leading impactful cancer research programs, including studies that address disparities.Apply for PAR 24 319
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "NCI Continuing Umbrella of Research Experiences (CURE) Mentored Clinical Scientist Research Career Development Award (K08 Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.398.
- This funding opportunity was created on 2024-12-06.
- Applicants must submit their applications by 2028-01-07.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is this grant opportunity?
The NCI Continuing Umbrella of Research Experiences (CURE) Mentored Clinical Scientist Research Career Development Award is an NIH career development award (K08) offered by the National Cancer Institute (NCI). The specific opportunity referenced is PAR-24-319 (CFDA 93.398) and it is labeled "K08 Clinical Trial Required."
What is the main purpose of the NCI CURE K08 award?
The main purpose is career development for clinically trained investigators in cancer-related research. It provides funding and protected time for several years of intensive, closely supervised research and training so the awardee can progress from mentored training to scientific independence and readiness to lead their own funded research program.
Who is the award designed to support?
The award is specifically aimed at advancing the careers of individuals from backgrounds that are nationally underrepresented in health-related science, within the NCI CURE framework. It is intended for clinicians with a doctoral clinical degree who are developing into independent clinical scientists in cancer-related research.
What kinds of research does this K08 support?
This K08 is centered on developing clinical scientists in basic biomedical, behavioral, or translational cancer research. It also explicitly includes research focused on cancer health disparities.
What does "mentored" mean in the context of this award?
It means the award is built around a structured plan in which the candidate conducts research and completes training under close supervision. The overall expectation is that mentorship and training will strengthen research skills, publication output, and grant-writing readiness while moving the candidate toward independence.
What does "Clinical Trial Required" mean for applicants?
It means the proposed career development research plan must include a clinical trial component as defined by NIH policy. This requirement influences both the research plan and the training environment, since the candidate typically needs appropriate clinical trial mentorship and access to clinical research infrastructure and regulatory support.
Why does clinical trial infrastructure matter for this K08?
Because the award requires a clinical trial component, the candidate generally needs a setting with the systems and support needed to run a trial responsibly and successfully, including regulatory support and experienced clinical trial mentorship.
How does this award help recipients beyond the immediate project?
The award is intended to help recipients build a stronger research skillset, publication track record, and grant-writing readiness. A key expected outcome is that recipients will be well-positioned to compete for later NIH research funding, such as R03, R21, or R01 awards.
Is this program focused only on cancer biology?
No. The opportunity includes basic biomedical research, behavioral research, and translational cancer research, and it also includes work addressing cancer health disparities.
Which federal agency runs this opportunity?
The opportunity is run by the National Cancer Institute (NCI), which is part of the National Institutes of Health (NIH).
What is the funding activity area and grant type?
The listing categorizes it as a discretionary grant in the Education and Health funding activity area.
What organizations are eligible to apply?
A wide range of applicant organizations may apply, including:
- Public and private institutions of higher education
- State and local governments
- Federally recognized tribal governments
- Tribal organizations (including those other than federally recognized tribal governments)
- Independent school districts
- Special district governments
- Public housing/Indian housing authorities
- Nonprofits (with or without 501(c)(3) status)
- For-profit organizations (other than small businesses)
- Small businesses
Are minority-serving institutions specifically highlighted as eligible?
Yes. The notice highlights eligibility for multiple types of institutions and organizations, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Are other organization types mentioned as eligible?
Yes. The listing also notes eligible federal agencies, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions.
Are foreign organizations eligible to apply?
No. Foreign entities are not eligible to apply.
Can a U.S. organization include a non-U.S. component?
No. Non-U.S. components of U.S. organizations are not eligible.
Are foreign components allowed under NIH policy?
No. Foreign components (as NIH defines them in the NIH Grants Policy Statement) are not allowed for this opportunity.
What is the closing date shown for this opportunity?
The listing includes an original closing date of January 7, 2028.
What is the creation date shown for this opportunity?
The listing includes a creation date of December 6, 2024.
Is the award ceiling listed in the provided information?
No. The award ceiling is not specified in the provided source text.
Is the expected number of awards provided?
No. The expected number of awards is not specified in the provided source text.
What should applicants infer from the fact that budget details are not specified here?
The provided text notes that this can be common for NIH career development announcements, where the budget structure is often governed by institute-specific salary and research development support limits described in the full funding announcement.
What is the overall outcome the program is trying to achieve?
The program is positioned as a structured bridge for underrepresented clinician-scientists in cancer research. The aim is to provide mentored training, time, and resources so recipients can transition into independent investigators capable of leading impactful, competitively funded cancer research programs, including research that addresses disparities.
What identifying numbers are associated with this opportunity?
The opportunity number is PAR-24-319, and the CFDA listing identifier provided is 93.398.
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| Funding Opportunity |
|---|
| NCI Continuing Umbrella of Research Experiences (CURE) Mentored Clinical Scientist Research Career Development Award (K08 Clinical Trial Not Allowed) Apply for PAR 24 320 Funding Number: PAR 24 320 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Research to Address Systemic and Structural Barriers and Facilitators to Improve the HIV Pre-Exposure Prophylaxis (PrEP) Care Continuum for People Who Use Substances (R34 Clinical Trials Required) Apply for RFA DA 26 004 Funding Number: RFA DA 26 004 Agency: National Institutes of Health Category: Education, Health Funding Amount: $225,000 |
| Research to Address Systemic and Structural Barriers and Facilitators to Improve the HIV Pre-Exposure Prophylaxis (PrEP) Care Continuum for People Who Use Substances (R01 Clinical Trials Required) Apply for RFA DA 26 003 Funding Number: RFA DA 26 003 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Interventions to Address Disparities in Liver Diseases and Liver Cancer (R01 - Clinical Trials Optional) Apply for PAR 25 299 Funding Number: PAR 25 299 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Accelerating the Pace of Substance Use Research Using Existing Data (R21 Clinical Trial Not Allowed) Apply for RFA DA 26 056 Funding Number: RFA DA 26 056 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Accelerating the Pace of Substance Use Research Using Existing Data (R01 Clinical Trial Not Allowed) Apply for RFA DA 26 055 Funding Number: RFA DA 26 055 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Pilot Health Services and Economic Research on the Treatment of Drug, Alcohol, and Tobacco Use Disorders (R34 Clinical Trial Optional) Apply for PAR 25 100 Funding Number: PAR 25 100 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Interventions to Reduce Sleep Health Disparities (R01 - Clinical Trials Optional) Apply for PAR 24 330 Funding Number: PAR 24 330 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Informatics Tools for the Pangenome (U01 Clinical Trial Not Allowed) Apply for RFA HG 25 007 Funding Number: RFA HG 25 007 Agency: National Institutes of Health Category: Education, Health Funding Amount: $400,000 |
| Exploratory/Developmental Bioengineering Research Grants (EBRG) (R21 Clinical Trial Optional) Apply for PAR 25 321 Funding Number: PAR 25 321 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Exploratory/Developmental Bioengineering Research Grants (EBRG) (R21 Clinical Trial Not Allowed) Apply for PAR 25 346 Funding Number: PAR 25 346 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Model Continuums of Care Initiative (MCCI) to Advance Health Equity and End Health Disparities Among Women and Girls in Racial/Ethnic Minority and Other Underserved Communities (U34 Clinical Trials Required) Apply for RFA AA 24 012 Funding Number: RFA AA 24 012 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Risk and Protective Factors of Family Health and Family Level Interventions (R01 Clinical Trial Optional) Apply for PAR 25 317 Funding Number: PAR 25 317 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Integrating Biospecimen Science Approaches into Clinical Assay Development (U01 Clinical Trial Not Allowed) Apply for PAR 25 325 Funding Number: PAR 25 325 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| D-START: Data Science Track Award for Research Transition (D/START) (R03-Clinical Trial Optional) Apply for PAS 25 236 Funding Number: PAS 25 236 Agency: National Institutes of Health Category: Education, Health Funding Amount: $100,000 |
| Innovative Biospecimen Science Technologies for Basic and Clinical Cancer Research (R61 Clinical Trial Not Allowed) Apply for RFA CA 25 003 Funding Number: RFA CA 25 003 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Innovative Molecular and Cellular Analysis Technologies for Basic and Clinical Cancer Research (R61 Clinical Trial Not Allowed) Apply for RFA CA 25 001 Funding Number: RFA CA 25 001 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Advanced Development and Validation of Emerging Biospecimen Science Technologies for Basic and Clinical Cancer Research (R33 Clinical Trial Not Allowed) Apply for RFA CA 25 004 Funding Number: RFA CA 25 004 Agency: National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| Advanced Development and Validation of Emerging Molecular and Cellular Analysis Technologies for Basic and Clinical Cancer Research (R33 Clinical Trial Not Allowed) Apply for RFA CA 25 002 Funding Number: RFA CA 25 002 Agency: National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| Toward Translation of Nanotechnology Cancer Interventions (TTNCI; R01 Clinical Trial Not Allowed) Apply for PAR 25 336 Funding Number: PAR 25 336 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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