Opportunity Information: Apply for PA 18 157
The Innovative Questions in Symptom Science and Genomics (R21 Clinical Trial Optional) funding opportunity (PA-18-157) is a discretionary NIH grant program designed to spark high-impact, early-stage research in nursing science at the intersection of symptom science and genomics. Its central purpose is to push the field toward genuinely new ideas by encouraging projects that grow out of explicitly identified "innovative questions" rather than incremental extensions of existing work. In practice, this means the program is looking for studies that can open up new conceptual territory, generate fresh insights about symptoms and their biological underpinnings, and demonstrate cutting-edge approaches or technologies that could change how symptom science is studied or applied.
The scientific focus is on symptom and genomic nursing science, with an emphasis on breakthroughs in concepts, methods, and tools. The opportunity frames the "innovative questions" as broad domains that applicants can translate into specific, testable hypotheses or clearly defined problems to solve. The intent is to catalyze exploratory and developmental research that may be novel, higher-risk, or not yet fully supported by extensive preliminary data, but that has strong potential to move the science forward. Because the announcement is clinical trial optional, applicants may propose studies that include a clinical trial if it fits the aims, but they are not required to do so; non-trial mechanistic, observational, methodological, or technology-development work may also be appropriate as long as it aligns with the symptom-genomics innovation emphasis.
This is an R21 mechanism, which typically supports exploratory, pilot, or proof-of-concept projects intended to generate key data, validate a new measurement or analytic approach, or establish feasibility for a larger future study. The listed award ceiling is $200,000, signaling a smaller, focused budget consistent with early-stage innovation. The opportunity is administered by the National Institutes of Health (NIH) under CFDA 93.361, and the activity category is listed as Education and Health, reflecting its placement within NIH biomedical and behavioral research priorities with a nursing science orientation.
Eligibility is broad and includes many types of U.S. organizations and governments: state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; and public housing authorities/Indian housing authorities. Tribal eligibility includes federally recognized Native American tribal governments and other Native American tribal organizations that are not federally recognized tribal governments. The announcement also welcomes nonprofit organizations both with and without 501(c)(3) IRS status (outside higher education), as well as for-profit organizations (other than small businesses) and small businesses. In addition, it explicitly calls out a wide range of "other eligible applicants," including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and even non-U.S. (foreign) entities.
Key administrative details included in the source information are the opportunity number (PA-18-157), the original closing date (2019-05-07), and the creation date (2017-11-07). While the expected number of awards is not specified in the provided text, the overall structure indicates a competitive NIH program meant to seed multiple innovative projects rather than fund a single large initiative. Taken together, the opportunity is best understood as a targeted NIH R21 call meant to accelerate novel, potentially transformative research directions in symptom science and genomics within nursing science, using a flexible clinical trial optional format and welcoming a wide variety of applicant organizations, including institutions serving underrepresented populations and entities located outside the United States.Apply for PA 18 157
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Innovative Questions in Symptom Science and Genomics (R21 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361.
- This funding opportunity was created on 2017-11-07.
- Applicants must submit their applications by 2019-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| Funding Opportunity |
|---|
| Self-Management Interventions and Technologies to Sustain Health and Optimize Functional Capabilities (R21 Clinical Trial Optional) Apply for PA 18 164 Funding Number: PA 18 164 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Palliative Care Needs of Individuals with Rare Advanced Diseases and Their Family Caregivers (R21 Clinical Trial Optional) Apply for PA 18 167 Funding Number: PA 18 167 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Improving Individual and Family Outcomes through Continuity and Coordination of Care in Hospice (R21 Clinical Trial Optional) Apply for PA 18 166 Funding Number: PA 18 166 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Short-term Mentored Career Enhancement Awards for Mid-Career Investigators to Integrate Basic Behavioral and Social Sciences (K18 - No Independent Clinical Trials) Apply for PAR 18 349 Funding Number: PAR 18 349 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Altered neuronal circuits, receptors and networks in HIV-induced Central Nervous System (CNS) dysfunction (R01)-Clinical Trial Not Allowed Apply for RFA MH 18 610 Funding Number: RFA MH 18 610 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Linking the Provider Recommendation to Adolescent HPV Vaccine Uptake (R01 Clinical Trial Optional) Apply for PAR 18 008 Funding Number: PAR 18 008 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Linking the Provider Recommendation to Adolescent HPV Vaccine Uptake (R21 Clinical Trial Optional) Apply for PAR 18 019 Funding Number: PAR 18 019 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Promoting Caregiver Health Using Self-Management (R01 Clinical Trial Optional) Apply for PA 18 150 Funding Number: PA 18 150 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Chronic Condition Self-Management in Children and Adolescents (R01 Clinical Trial Optional) Apply for PA 18 151 Funding Number: PA 18 151 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Reducing Health Disparities Among Minority and Underserved Children (R01 Clinical Trial Optional) Apply for PA 18 152 Funding Number: PA 18 152 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Chronic Condition Self-Management in Children and Adolescents (R21 Clinical Trial Optional) Apply for PA 18 168 Funding Number: PA 18 168 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Reducing Health Disparities Among Minority and Underserved Children (R21 Clinical Trial Optional) Apply for PA 18 169 Funding Number: PA 18 169 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Mechanism for Time-Sensitive Drug Abuse Research (R21 Clinical Trial Optional) Apply for PAR 18 064 Funding Number: PAR 18 064 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Population Health Interventions: Integrating Individual and Group Level Evidence (R21)- Clinical Trials Not Allowed Apply for PA 18 357 Funding Number: PA 18 357 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| International Research Collaboration on Drug Abuse and Addiction Research (R03 Clinical Trial Optional) Apply for PA 18 065 Funding Number: PA 18 065 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Pilot and Feasibility Studies in Preparation for Drug and Alcohol Abuse Prevention Trials (R34 Clinical Trial Optional) Apply for PA 18 067 Funding Number: PA 18 067 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| International Research Collaboration on Drug Abuse and Addiction Research (R21 Clinical Trial Optional) Apply for PA 18 066 Funding Number: PA 18 066 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| AIDS-Science Track Award for Research Transition (R03 Clinical Trial Optional) Apply for PA 18 072 Funding Number: PA 18 072 Agency: National Institutes of Health Category: Education, Health Funding Amount: $100,000 |
| Stimulating Innovations in Behavioral Intervention Research for Cancer Prevention and Control (R21 Clinical Trial Optional) Apply for PAR 18 018 Funding Number: PAR 18 018 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Pilot Health Services and Economic Research on the Treatment of Drug, Alcohol, and Tobacco Abuse (R34 Clinical Trial Optional) Apply for PA 18 068 Funding Number: PA 18 068 Agency: National Institutes of Health Category: Education, Health Funding Amount: $225,000 |
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