HIV Prevention Among Adolescent Girls and Young Women and Other Vulnerable Youth Populations - DREAMS North | 72067425RFA00001

Opportunity Information: Apply for 72067425RFA00001

The USAID South Africa mission in Pretoria is soliciting applications for a discretionary health cooperative agreement titled "HIV Prevention Among Adolescent Girls and Young Women and Other Vulnerable Youth Populations - DREAMS North" (Funding Opportunity Number 72067425RFA00001). The central purpose of the activity is to substantially reduce new HIV infections among adolescent girls and young women (AGYW) ages 10 to 24 in selected high-burden areas of South Africa. The program is framed around the idea that HIV incidence can be driven down by expanding AGYW access to a comprehensive, age-appropriate package of prevention services that are grounded in evidence and that directly tackle the main drivers of risk, including biological factors, behavioral risks, and socio-economic vulnerabilities.

The proposed activity focuses on delivering an integrated prevention approach rather than a single intervention. It emphasizes improving availability and uptake of interventions designed for different age bands within 10-24, recognizing that younger adolescents and older young women often face different risks and barriers to care. Within the prevention package, the opportunity explicitly prioritizes reliable access to contraception, sexually transmitted infection (STI) treatment, and post-exposure prophylaxis (PEP), signaling a strong expectation that the implementer will ensure these commodities and services are accessible, appropriately targeted, and delivered in a way that is practical for young people to use. The overall intent aligns with DREAMS-style programming, which typically combines clinical services with community and structural supports to reduce vulnerability and make prevention options realistic and sustainable.

Geographically, the activity is anticipated to operate in three provinces described as areas with the highest HIV incidence and prevalence. In Mpumalanga, the anticipated districts are Gert Sibanda, Nkangala, and Ehlanzeni. In Gauteng, the areas include the City of Johannesburg and Sedibeng. In Limpopo, the anticipated districts are Mopani and Capricorn. Applicants should read this as a clear sign that implementation is expected to be concentrated in these specific localities, with programming designed around the needs, service landscape, and epidemic dynamics of these districts.

This funding opportunity is structured as a cooperative agreement, which generally means USAID expects substantial involvement during implementation (for example, ongoing coordination on work planning, monitoring, and adaptive management), rather than a hands-off grant model. The total ceiling amount listed is up to $58,000,000, and USAID anticipates making one award, suggesting a single prime partner will be responsible for leading and coordinating implementation across the targeted provinces and districts. The opportunity is listed under CFDA 98.001 and categorized under health.

Eligibility is restricted to local South African entities, meaning only organizations that meet the NOFO's definition of a local entity are allowed to apply. Any interested applicant would need to rely on the full Notice of Funding Opportunity for the precise eligibility tests and documentation requirements. Key dates included in the posting indicate the opportunity was created on December 13, 2024, with an original closing date of February 11, 2025.

• The South Africa USAID-Pretoria in the health sector is offering a public funding opportunity titled "HIV Prevention Among Adolescent Girls and Young Women and Other Vulnerable Youth Populations - DREAMS North" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 98.001.
• This funding opportunity was created on 2024-12-13.
• Applicants must submit their applications by 2025-02-11. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $58,000,000.00 in funding.
• The number of recipients for this funding is limited to 1 candidate(s).
• Eligible applicants include: Others.

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