Early Psychosis Intervention Network (EPINET) Data Coordinating Center (U24 Clinical Trial Not Allowed) | RFA MH 24 106

Opportunity Information: Apply for RFA MH 24 106

The Early Psychosis Intervention Network (EPINET) Data Coordinating Center opportunity (RFA-MH-24-106) is a National Institute of Mental Health (NIMH), NIH discretionary funding announcement that will support a central data coordinating center through a U24 cooperative agreement mechanism (clinical trial not allowed). The intent is to strengthen and extend NIMH investment in large-scale T3/T4 translational research focused on real-world implementation and population-level impact. In practical terms, the award is meant to provide the shared data infrastructure, coordination, and analytic support needed to improve early identification of psychosis, evaluate and enhance the effectiveness of early interventions, and ultimately improve long-term outcomes for adolescents and young adults experiencing a first episode of psychosis. This U24 is designed to function alongside a companion program for P01 regional early psychosis networks, meaning the data coordinating center is expected to serve as the backbone that helps multiple regional networks operate with consistent data standards, harmonized measures, and comparable outcomes tracking.

Because this is a cooperative agreement, the award structure implies substantial NIH program involvement in shaping goals, ensuring collaboration across sites, and guiding network-wide activities rather than a fully investigator-initiated model. The Data Coordinating Center role typically includes building and maintaining a secure and scalable data platform; developing common data elements and governance policies; supporting data quality assurance, data harmonization, and cross-site reporting; and enabling pooled analyses that can answer larger questions than any single site could address alone. The overall research emphasis is on later-stage translation (T3/T4), which generally means moving evidence-based practices into routine care settings, testing strategies that improve uptake and fidelity, measuring outcomes that matter for services and communities, and generating findings that can inform policy and system-level decisions for early psychosis care.

Eligibility is broad and includes many U.S.-based organizational types: state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and other eligible entities. The announcement also highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal government agencies, faith-based or community-based organizations, regional organizations, Indian/Native American tribal governments that are not federally recognized, and U.S. territories or possessions. At the same time, there are clear restrictions related to foreign involvement: non-domestic (non-U.S.) entities are not eligible to apply, non-domestic components of U.S. organizations are not eligible, and foreign components (as defined by the NIH Grants Policy Statement) are not allowed.

Administratively, this opportunity sits within NIH’s health funding area and is associated with CFDA 93.242. The original application closing date was March 29, 2024, and the listed award ceiling is $1,000,000. The funding announcement was created on November 28, 2023. The listing does not provide a specific expected number of awards in the provided source data, but the structure and purpose suggest a single coordinating center award intended to serve multiple regional network sites. Overall, the opportunity is best understood as funding the centralized operational and scientific data hub for EPINET, enabling consistent measurement, data sharing, and rigorous multi-site evaluation of early psychosis identification and intervention strategies in real-world settings, with the long-term goal of improving outcomes for young people at the start of psychotic illness.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Early Psychosis Intervention Network (EPINET) Data Coordinating Center (U24 Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242.
• This funding opportunity was created on 2023-11-28.
• Applicants must submit their applications by 2024-03-29. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $1,000,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA MH 24 106

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